Journal article
Systemic haemodynamic, renal perfusion and renal oxygenation responses to changes in inspired oxygen fraction during total intravenous or volatile anaesthesia
N Iguchi, J Kosaka, Y Iguchi, RG Evans, R Bellomo, CN May, YR Lankadeva
British Journal of Anaesthesia | ELSEVIER SCI LTD | Published : 2020
Abstract
Background: Anaesthesia-induced changes in renal perfusion are dependent on the choice of anaesthetic agent. However, the effects of varying inspired oxygen fraction (FiO2) on renal perfusion and oxygenation during TIVA (propofol + fentanyl) or volatile anaesthesia (VA; isoflurane) are unknown. Methods: In 16 Merino ewes, we surgically implanted a renal artery flow probe and laser-Doppler and oxygen-sensing probes in the renal medulla and cortex. We compared the systemic and renal effects of graded alterations in FiO2 (0.21, 0.40, 0.60, and 1.0) during TIVA or VA and compared the changes with those in the non-anaesthetised state. Results: Compared with the non-anaesthetised state, TIVA and V..
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Awarded by State Government of Victoria
Funding Acknowledgements
This study was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC, 1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant. YRL was supported by a FutureLeader Fellowship from the National Heart Foundation of Australia (NHF, 101853) and an Early Career Medical Research Grant from the Jack Brockhoff Foundation (JBF 4178).